Are you a recent or soon-to-be PhD graduate in immunology or a related field? Want to develop novel therapeutics for lung disease/lung transplantation?
The CLAD team is looking for a postdoctoral fellow through the UHN Canada Leads opportunity: https://www.uhn.ca/corporate/AboutUHN/canadaleads
Please contact Dr. Juvet at Stephen.juvet@uhn.ca if interested.
July 22, 2025
Congratulations to our CLAD Team members for their outstanding achievements at Respirology Research Day!
Sumiha Karunagaran (PhD. Candidate) was awarded Top Basic Science Oral Abstract for her presentation:
"Evidence for a neuro-immune axis associated with local B cell responses and fibrosis in chronic lung allograft rejection"
Dr. Julie Semenchuk (PhD. Candidate) was awarded Best Poster Presentation for her work:
"Characteristics of a first episode of acute lung allograft dysfunction (ALAD) and the risk of chronic lung allograft dysfunction (CLAD) following lung transplant"
June 12, 2025
We’re proud to share that Allen Duong (PhD. Candidate) received the Top Basic/Translational Science Abstract Award at the Ajmera Transplant Centre Research Conference for his outstanding work on:
"In vitro characterization of pro-inflammatory LILRB2⁺ and pro-fibrotic SPP1⁺ pulmonary macrophages in chronic lung allograft dysfunction"
June 5, 2025
We’re excited to announce that Nicole Chrysler (MSc. Candidate) has been awarded the ISHLT Early Career Scientist 2025 Award for her impactful research on:
"Anti-Donor T Cell Dynamics and CLAD Risk in the Assessment of Lung Allograft Rejection – Measurement of T Cell Immune Synapses (ALARM-T) Study"
April 2025
April 2025
We’re thrilled to share that Dr. Stephen Juvet has been awarded the ISHLT Molecular Biomarker Study Using Artificial Intelligence/Machine Learning Analysis in Lung Transplantation Grant for groundbreaking work led by Daniel Vosoughi (PhD. Candidate) on:
“A Machine Learning–Enhanced Lung-Specific Autoantibody Signature to Identify Patients at Risk for CLAD”
We’re excited to share a new publication from our team:
"Emergence of a senescent and inflammatory pulmonary CD4⁺ T cell population prior to lung allograft failure"
by Moshkelgosha S, Bernard A, Martinu T, Juvet S, et al.
Published in Science Advances – March 21, 2025
Read the full article here
This study identifies a novel population of CD4⁺CD57⁺PD1⁺ T cells in the lungs of transplant patients that emerges before the onset of graft dysfunction and predicts progression to CLAD and poorer survival.
Congratulations to Dr. Moshkelgosha and all the authors on this important contribution!
March 21, 2025