Publications

Recent Publications

Duong A, Moshkelgosha S, Martinu T, Juvet S. Refining cell-type annotation and fibrotic comparisons in chronic lung allograft dysfunction in single-cell RNA sequencing studies. JCI Insight. 2026 Aug 20:e208925. doi: 10.1172/jci.insight.208925. Epub ahead of print. PMID: 42623155.

Duong A, Mariscal A, Caldarone L, Xu C, Huang L, Ramendra R, Keshavjee S, Liu M, Juvet S, Martinu T. Characterizing the myeloid and lymphoid immune response in a porcine model of pulmonary ischemia-reperfusion injury through flow cytometry. PLoS One. 2026 May 21;21(5):e0344691. doi: 10.1371/journal.pone.0344691. PMID: 42166474; PMCID: PMC13193541.

Takahagi A, Miyamoto E, Lam C, Liu M, Joe B, Wang X, Hwang D, Martinu T, Cypel M, Keshavjee S, Juvet S. Permissive immunosuppression facilitates the expansion of ex vivo administered regulatory T cells in the lung allograft. Sci Rep. 2025 Jul 2;15(1):22897. doi: 10.1038/s41598-025-06835-8. PMID: 40594529; PMCID: PMC12217019.

Miyamoto E, Ohsumi A, Hwang D, Boonstra K, Cypel M, Martinu T, Keshavjee S, Juvet SC. Ex vivo lung perfusion-to-lung transplant rat survival model with reproducible development of acute lung injury and graft rejection. JHLT Open. 2025 May 26;9:100299. doi: 10.1016/j.jhlto.2025.100299. PMID: 40530004; PMCID: PMC12173122.

Moshkelgosha S, Levy L, Safavi S, Karunagaran S, Wilson G, Renaud-Picard B, Madu G, Ramchandani R, Oliver J, Watanabe T, Bei KF, Joe B, Li Q, Huszti E, Cheung M, Hedley D, Yeung J, Keshavjee S, Martinu T, Juvet S. Emergence of a senescent and inflammatory pulmonary CD4+ T cell population prior to lung allograft failure. Sci Adv. 2025 Mar 21;11(12):eadp9052. doi: 10.1126/sciadv.adp9052. Epub 2025 Mar 21. PMID: 40117366; PMCID: PMC11927631.

Vosoughi D, Ulahannan A, Li Q, Huszti E, Chruscinski A, Birriel D, Madu G, Teskey G, Aversa M, Martinu T, Juvet S. Humoral immunity to lung antigens early post-transplant confers risk for chronic lung allograft dysfunction. J Heart Lung Transplant. 2025 Feb 17:S1053-2498(25)01661-4. doi: 10.1016/j.healun.2025.02.1577. Epub ahead of print. PMID: 39971216.

Juvet S, Cypel M. All Cloak and No Dagger? Immunosuppression-free Lung Transplantation by Sustained Knockdown of Major Histocompatibility Complex Expression in the Graft. Transplantation. 2025 Feb 11. doi: 10.1097/TP.0000000000005351. Epub ahead of print. PMID: 39930558.

Levy L, Moshkelgosha S, Huszti E, Wang S, Hunter S, Zhang CYK, Ghany R, Keshavjee S, Singer LG, Tikkanen J, Juvet S, Martinu T. Bronchoalveolar lavage cytokine-based risk stratification of clinically-stable lung transplant recipients with undefined rejection: Further insights from a follow-up investigation. J Heart Lung Transplant. 2024 Nov 19:S1053-2498(24)01967-3. doi: 10.1016/j.healun.2024.11.020. Epub ahead of print. PMID: 39571635.

Renaud-Picard B, Moshkelgosha S, Berra G, Cheung M, Hwang D, Hedley D, Juvet S, Martinu T. Detailed cellular and spatial characterization of chronic lung allograft dysfunction using imaging mass cytometry. J Heart Lung Transplant. 2024 Oct 3:S1053-2498(24)01875-8. doi: 10.1016/j.healun.2024.09.023. Epub ahead of print. PMID: 39368678.

Miyamoto E, Vosoughi D, Wang J, Al-Refaee J, Berra G, Daigneault T, Duong A, Joe B, Moshkelgosha S, Keshavjee S, Tinckam K, Hwang D, Chruscinski A, Juvet S, Martinu T. Local intragraft humoral immune responses in chronic lung allograft dysfunction. J Heart Lung Transplant. 2024 Aug 7:S1053-2498(24)01752-2. doi: 10.1016/j.healun.2024.07.019. Epub ahead of print. PMID: 39097215.

Beber SA, Moshkelgosha S, White M, Zehong G, Cheung M, Hedley D, Levy L, Samuels J, Renaud-Picard B, Hwang D, Martinu T, Juvet S. The CD8+ T cell content of transbronchial biopsies from patients with a first episode of clinically stable grade A1 cellular rejection is associated with future chronic lung allograft dysfunction. J Heart Lung Transplant. 2024 Oct;43(10):1654-1664. doi: 10.1016/j.healun.2024.06.001. Epub 2024 Jun 7. PMID: 38852935.

Renaud-Picard B, Berra G, Hwang D, Huszti E, Miyamoto E, Berry GJ, Pal P, Juvet S, Keshavjee S, Martinu T. Spectrum of chronic lung allograft dysfunction pathology in human lung transplantation. J Heart Lung Transplant. 2024 Oct;43(10):1701-1715. doi: 10.1016/j.healun.2024.04.002. Epub 2024 Apr 23. PMID: 38663465.

Kawashima M, Ma J, Huszti E, Levy L, Berra G, Renaud-Picard B, Takahagi A, Ghany R, Sato M, Keshavjee S, Singer L, Husain S, Kumar D, Tikkanen J, Martinu T. Association between cytomegalovirus viremia and long-term outcomes in lung transplant recipients. Am J Transplant. 2024 Jun;24(6):1057-1069. doi: 10.1016/j.ajt.2024.01.027. Epub 2024 Feb 1. PMID: 38307417.

Ramendra R, Duong A, Zhang CYK, Huszti E, Zhou X, Havlin J, Ghany R, Cypel M, Yeung JC, Keshavjee S, Sage AT, Martinu T. Airway pepsinogen A4 identifies lung transplant recipients with microaspiration and predicts chronic lung allograft dysfunction. J Heart Lung Transplant. 2024 Jun;43(6):973-982. doi: 10.1016/j.healun.2024.01.002. Epub 2024 Jan 10. PMID: 38211836.